Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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2,161 – 2,175 of 4,396 results

2,161

Apexbio Technology LLC SKF38393 HCl 62717-42-4 200mg

SKF38393 HCl is a selective dopamine D1 receptor agonist exhibiting activity through direct binding and stimulation of D1 receptors Activation of D1 receptors primarily induces adenylyl cyclase stimulation and increases cAMP-dependent protein kinase signaling subsequently modulating neuronal differentiation growth and dopamine-mediated functional responses Experimental evidence indicates that SKF38393 administration impacts gene expression patterns related to dopamine receptor-sensitive neuronal pathways and neuropeptides Additionally in vitro studies report SKF38393 to inhibit proliferation of certain tumor cell lines exemplified by decreased cell growth in breast carcinoma-derived MCF-7 cells at submicromolar concentrations It is widely utilized as a pharmacological tool in neuroscience and oncology research

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2,162

Apexbio Technology LLC MHY1485 326914-06-1 200mg

MHY1485 (CAS 326914-06-1) is a potent activator of mammalian target of rapamycin (mTOR) a serine/threonine kinase critical for cellular growth metabolism and survival pathways By activating mTOR signaling MHY1485 inhibits autophagy initiation and disrupts the fusion step between autophagosomes and lysosomes resulting in accumulation of autophagic marker LC3-II and enlarged autophagic structures In cultured rat Ac2F hepatic cells MHY1485 suppresses basal and starvation-induced autophagic flux Additionally MHY1485 treatment promotes ovarian follicular development and increases explant growth in mouse ovarian culture models providing a useful tool in biomedical research of mTOR signaling and reproductive biology

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2,163

Apexbio Technology LLC Torin 2 1223001-51-1 200mg

Torin 2 (CAS 1223001-51-1) is a selective orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) exhibiting an EC50 of approximately 0 25 nM Structurally improved from Torin 1 Torin 2 interacts via hydrogen bonding with residues V2240 and Y2225 in mTOR and two additional interactions between its aniline amino group and residues D2195 and D2357 enhancing potency and pharmacokinetic properties It displays high selectivity for mTOR over phosphoinositide 3-kinases (PI3Ks) and other protein kinases by nearly 800-fold Due to these properties Torin 2 is extensively studied in oncological research targeting mTOR signaling pathways

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2,164

Apexbio Technology LLC KN-92 176708-42-2 200mg

KN-92 is a structurally related but inactive analog of the CaMKII inhibitor KN-93 primarily utilized as a negative control compound in investigations of Ca2 /calmodulin-dependent kinase II (CaMKII) function Unlike KN-93 KN-92 does not effectively interfere with the binding of calmodulin (CaM) to the CaMKII enzyme and does not demonstrate substantial inhibition of CaMKII catalytic activity As a molecular control KN-92 allows researchers to distinguish between CaMKII-specific inhibitory effects and potential non-specific cellular influences when employing KN-93 in experimental models KN-93 itself selectively interacts with the CaM-binding region of CaMKII impeding enzyme activity implicated in cellular responses such as calcium-induced calcium release in cardiac cells histamine-stimulated aminopyrine uptake in gastric parietal cells and calcium-dependent induction of HIF-1 in cancer cells

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2,165

Medchemexpress LLC Phentolamine mesylate | 65-28-1 | 99.9% | 1 ML

Phentolamine mesylate (Phentolamine methanesulfonate) is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptors that expands blood vessels to reduce peripheral vascular resistance. It can be used for the research of pheochromocytoma-related hypertension, heart failure, and erectile dysfunction.

Reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptors
Expands blood vessels to reduce peripheral vascular resistance
Used for research of pheochromocytoma-related hypertension
Used for research of heart failure
Used for research of erectile dysfunction

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2,166

TARGETMOL CHEMICALS INC KRM-III 5MG

Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. KRM-III is an orally active T cell antigen receptor (TCR) inhibitor with anti-inflammatory activity that potently inhibits TCR and myristate acetate/fosfomycin/ionomycin-induced NFAT nuclear factor activation and T cell proliferation with an IC50 of approximately 5 uM. purity: 99%

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2,167

Medchemexpress LLC Desonide | 638-94-8 | 99.2% | 200 MG

Desonide is a non-fluorinated corticosteroid anti-inflammatory agent that acts on the glucocorticoid receptor. It can also specifically bind to the mutant huntingtin protein (mHTT), reducing the level and toxicity of mHTT. Desonide can be used in the research of Huntington's disease and inflammatory diseases such as atopic dermatitis.

Non-fluorinated corticosteroid anti-inflammatory agent
Modulates glucocorticoid receptor activity
Specifically binds to mutant huntingtin protein (mHTT)
Reduces mutant huntingtin protein (mHTT) levels and toxicity
Used in Huntington's disease research
Used in inflammatory disease research, such as atopic dermatitis
Inhibits mHTT-induced cytotoxicity
Reduces apoptotic signals and improves cell survival
Demonstrates therapeutic effects in Huntington's disease mouse models
Rescues behavioral deficits and lowers mHTT aggregates

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2,168

Selleck Chemical LLC RESIQUIMOD R-848-1G

NC3234759 RESIQUIMOD R-848-1G

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2,169

Sigma Aldrich Fine Chemicals Biosciences Ciprofloxacin hydrochloride European Pharmacopoeia (EP) Reference Standard | 86393-32-0 | MFCD00242856 |

Ciprofloxacin hydrochloride European Pharmacopoeia (EP) Reference Standard | Mol Wt: 385.82 | 86393-32-0 | MFCD00242856 |

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2,170

Medchemexpress LLC Quinine hydrochloride dihydrate | 6119-47-7 | 99.7% | 10 G

Quinine hydrochloride dihydrate is an orally active compound primarily used in anti-malarial studies. It functions as a potassium channel inhibitor, specifically targeting WT mouse Slo3 (KCa5.1) channel currents. This compound has also demonstrated effects against Dengue virus proliferation in HepG2 cell lines and exhibited some tumor-suppressing activity in skin cancer models.

Acts as a potassium channel inhibitor
Inhibits WT mouse Slo3 (KCa5.1) channel currents
Inhibits DENV proliferation and cytostatic effects in HepG2 cell lines
Reduces viral DENV RNA and protein levels
Shows tumor-suppressing effects on skin cancer in mice

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2,171

eMolecules 58794-09-5 | 7-Bromoisoquinoline | Ambeed | MFCD07368661 | 208.058 | C9H6BrN | 97.000 | Brc1ccc2ccncc2c1 | 10g | 525052807

7-Bromoisoquinoline | Ambeed | 58794-09-5 | MFCD07368661 | 208.058 | C9H6BrN | 97.000 | Brc1ccc2ccncc2c1 | 10g | 525052807

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2,172

eMolecules 2089251-33-0 | 1-Octylnonyl 8-[(2-hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]octanoate | Acrotein ChemBio Inc.710.182 | C44H87NO5 | 97.000 | CCCCCCCCCOC(=O)CCCCCCCN(CCO)CCCCCCCC(=O)OC(CCCCCCCC)CCCCCCCC | 1g | 825286052

1-Octylnonyl 8-[(2-hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]octanoate | Acrotein ChemBio Inc. | 2089251-33-0710.182 | C44H87NO5 | 97.000 | CCCCCCCCCOC(=O)CCCCCCCN(CCO)CCCCCCCC(=O)OC(CCCCCCCC)CCCCCCCC | 1g | 825286052

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2,173

AdipoGen Quinine anhydrous

Chemical. CAS 130-95-0. Formula C20H24N2O2. MW 324.42. Synthetic. Because of its relatively constant and well-known fluorescence quantum yield, quinine is also used in photochemistry as a common fluorescence standard. It has been used for imaging of oxygen evolution and oxide formation. Chloride and bromide have been shown to quench fluorescence. Generally it is famous as potassium channel blocker with antipyretic fever-reducing, antimalarial, analgesic painkilling, and anti-inflammatory properties.

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2,174

eMolecules 903129-71-5 | 6-Boc-2,4-dichloro-5,7-dihydropyrrolo[3,4-d]pyrimidine | Accela ChemBio (ASD) | MFCD08273919 | 290.140 | C11H13Cl2N3O2 | 95.000 | CC(C)(C)OC(=O)N1Cc2nc(Cl)nc(Cl)c2C1 | 25g | 686659375

6-Boc-2,4-dichloro-5,7-dihydropyrrolo[3,4-d]pyrimidine | Accela ChemBio (ASD) | 903129-71-5 | MFCD08273919 | 290.140 | C11H13Cl2N3O2 | 95.000 | CC(C)(C)OC(=O)N1Cc2nc(Cl)nc(Cl)c2C1 | 25g | 686659375

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2,175

Medchemexpress LLC Imiquimod | 99011-02-6 | 100.0% | 200 MG

Imiquimod is an immune response modifier that functions as a selective Toll-like Receptor 7 (TLR7) agonist. It demonstrates antiviral and antitumor effects in living organisms.

Selective TLR7 agonist.
Exhibits antiviral and antitumor properties in vivo.
Used for research related to external genital and perianal warts, cancer, and COVID-19.
Purity: 99.96%.

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Quinolines and derivatives

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Apexbio Technology LLC SKF38393 HCl 62717-42-4 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC MHY1485 326914-06-1 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC Torin 2 1223001-51-1 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC KN-92 176708-42-2 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Phentolamine mesylate | 65-28-1 | 99.9% | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

TARGETMOL CHEMICALS INC KRM-III 5MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Desonide | 638-94-8 | 99.2% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Selleck Chemical LLC RESIQUIMOD R-848-1G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Quinine hydrochloride dihydrate | 6119-47-7 | 99.7% | 10 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

AdipoGen Quinine anhydrous Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Imiquimod | 99011-02-6 | 100.0% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More